---
title: NUDT15 Kit
description: MEBRIGHT™ NUDT15 Kit is a reagent for assessing three types of alleles by detecting genetic polymorphism at codon 139 of the NUDT15 gene.
image: https://lp.mblbio.com/hubfs/NUDT15.png
---

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# ![nudt15_lp](https://lp.mblbio.com/hubfs/NUDT15LP/nudt15_lp.png)

## Prescribe Thiopurine drugs?

The thiopurine drugs are widely used to treat. However, the incidence of adverse reactions is high, particularly in Asia.  
NUDT15 genotyping is a good candidate for predicting thiopurine toxicity in East Asian populations. (Kakuta *et al*. 2018)

## MEBRIGHT™ NUDT15 Kit

Nudix hydrolase 15 (NUDT15) genetic polymorphism kit

- Predict risks of serious adverse events from thiopurine drugs\*.
- Detect the *NUDT15* codon 139 genetic polymorphism by RT-PCR.
- Useful support in selecting treatment options for patients with reduced NUDT15 activities.
- Approved as IVD by PMDA\*\* in Japan.

\***Thiopurine drugs** are used to treat patients such as **SLE, IBD** and **Behcet's disease**.  
\*\*PMDA: Pharmaceuticals and Medical Devices Agency

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## MEBRIGHT™ NUDT15 Kit

is a reagent for assessing three types of alleles by detecting genetic polymorphism at codon 139 of the *NUDT15* gene. The kit adopts the real-time PCR method and uses genome DNAs extracted from whole blood as specimens. The kit allows to predict patients with a high risk of serious adverse events from thiopurine drugs and provides support in selecting treatment options for those with reduced NUDT15 activities.

### \[ Polymorphisms detected with MEBRIGHT™ NUDT15 Kit \]

![codon139](https://lp.mblbio.com/hubfs/NUDT15LP/codon139.png)

### \[ Associations in *NUDT15* codon139 genotypes between MEBRIGHT™ NUDT15 Kit and severe adverse events \]

Detection results of this product and the incidence rate of side effects due to thiopurine-type immunoregulatory agents.

![leukopenia](https://lp.mblbio.com/hubfs/NUDT15LP/leukopenia.png)

![alopecia](https://lp.mblbio.com/hubfs/NUDT15LP/alopecia.png)

#### Reference

Kakuta *et al*. (2018). "Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping." Journal of Gastroenterology 53(2): 172-180.

MEBRIGHT™ is a registered trademark of Medical & Biological Laboratories Co., Ltd.

Products may not be approved for sale as in vitro diagnostics in all countries. Please contact us for further details.

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