WHITE PAPER
Generating Induced Intestinal Progenitor Cells by Direct Reprogramming
Author :
Shizuka Miura, Ph.D.
Division of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University
1. Introduction
The gut (intestine) is an internal organ with a range of functions, one of which includes the absorption of water and nutrients from external materials that have been ingested. Due to the nature of this material, the intestinal lumen is continuously exposed to potential sources of infection. Intestinal epithelial cells have a barrier function that prevents infection. Severe diseases, such as inflammatory bowel disease, are caused if this barrier function fails. Unfortunately this failure occurs by unknown mechanisms. For this reason,
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